Bioessence is the culmination of centuries of research and striving by the now-defunct Cabal to seek a replacement - indeed, a natural conclusion to - the art of Necromancy. As a northern successor, Bioessence combines the Spirean ideals of progress with a working knowledge of anatomy and biology. In addition to its scientific applications, wielders of the art employ it with a clinical ruthlessness to destroy their enemies, using a combined agent of shadow essence and elemental material known as the 'mutagen.'